If you haven't heard, the first Public Draft of the EPUB 3 was released, which significantly enhances support for math and science content in ebooks. The new specification gives you the ability to create math in enhanced ebooks that can be copied into calculation apps, math-based search, and other applications, as well as greater accessibility of mathematics for those with special needs.
EPUB 3 uses the information-rich MathML encoding for mathematics notation, whereas earlier versions of the EPUB format treated equations primarily as images. MathML is already being used by other applications and publishers, and has been adopted as the format of choice for the accessibility community. The new EPUB specifications will be able to better leverage existing technology (such as MathType and MathPlayer) as well as other production tools for math and science content.
For more discussion about the potential impact of EPUB 3 for math and science publishing, join the Ebooks for Math and Science group at Linked-in.